Researchers at TSU hope vaccine can cure breast cancer
A Tennessee State University scientist and a group of researchers from Washington University School of Medicine at St. Louis have come up with an experimental vaccine for breast cancer that appears to be safe in a preliminary trial.
According to a study published in Clinical Cancer Research, Dr. Venkataswarup Tiriveedhi, assistant professor of Biological Sciences in the College of Agriculture, Human and Natural Sciences, and his colleagues found that the experimental vaccine, Mammaglobin-A, was “overexpressed” in 40 to 80 percent of primary breast cancers.
Also known as MAM-A, the vaccine prompted CD8 T-cells to track and eliminate the MAM-A protein, noted Tiriveedhi. To determine the efficacy and safety of the experimental drug, he said they conducted a phase I trial involving 14 patients diagnosed with advanced breast cancer.
“The side effects from the vaccine after one year were minimal, and included rashes, tenderness, and mild flu-like symptoms,” added Tiriveedhi, who specializes in cancer and immunology.
The researchers, however, stressed the need for a larger and longer study, to prove the current preliminary evidence prior to its use in all breast cancer patients. They theorized that “these promising results” from initial studies could be applied not only to prevent cancer progression but also to prevent the development of breast cancer in women.