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Fulvestrant improves survival over anastrozole in advanced breast cancer

Fulvestrant improves survival over anastrozole in advanced breast cancer

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Among patients with advanced, hormone receptor-positive breast cancer who had not been treated previously for advanced disease, those who took fulvestrant lived longer than those who took anastrozole, according to data from the phase II FIRST trial presented at the 2014 San Antonio Breast Cancer Symposium.

“We found fulvestrant to be significantly better for women with advanced breast cancer than a third-generation aromatase inhibitor [anastrozole], which has been the most potent endocrine therapy thus far in the first-line setting for advanced disease,” said John Robertson, MD, professor of surgery at Graduate Entry Medical School at the University of Nottingham, Royal Derby Hospital, in the United Kingdom.

“Preliminary analysis from the FIRST phase II trial, which was reported previously, showed longer disease control with 500 mg fulvestrant during the treatment phase compared with anastrozole. The new data we report here translate our previous finding into improved overall survival,” Robertson added.

“Despite the improved disease control on treatment and improved overall survival seen in the FIRST study, we do not expect this to change the standard of care at this point since it was a phase II study,” Robertson explained. “A phase III [FALCON] study has been initiated to support the regulatory approval for fulvestrant as a first-line agent in this setting, which would be practice-changing.”

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